Neurobiology of Depression, Anxiety, and Stress

The neurobiology of depression, anxiety, and stress is driven by intricate interactions among neural circuits, neurotransmitter systems, and endocrine pathways. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, along with imbalances in serotonin, dopamine, and GABA signaling, plays a critical role in mood disorders. Structural and functional alterations in the prefrontal cortex, amygdala, and hippocampus are associated with emotional dysregulation. Chronic stress triggers neuroinflammation, reduced neurogenesis, and impaired synaptic plasticity, increasing susceptibility to anxiety and depressive disorders. Advances in neuroimaging, biomarker research, and understanding of neurotrophic factors enable precise diagnosis and development of targeted therapeutic interventions.

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